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Mildronate (Ripronate, Trimethylhydrazinium propionate, Angiocardil, Vasomag, Idrinol, Cardionate, Meldonate, Melfor, Mildzhen, Mildovel, Midolat, Mildrocard, Repronate VM, THP, Meldonium) is a drug that improves metabolism and tissue energy supply. The drug was created in the 1970s at the Institute of Organic Synthesis of the Latvian SSR, developed by Professor Ivars Kalvinsh. The compound was originally patented as a means to control plant growth and stimulate the growth of animals and poultry.
WADA views mildronate as a metabolic modulator similar to insulin. A study published in December 2015 in the journal "Drug Testing and Analysis" claims that meldronate improves athletes' performance, endurance, improves recovery from performance, protects against stress and increases central nervous system function. However, these effects have mainly been confirmed only by Latvian scientists.
As of 1 January 2016, meldonium has been added to class S4 (Hormones and Metabolic Modulators) of the Prohibited List and is prohibited for in- and out-of-competition use.
Mildronate has been one of the main components of pharmacological support for domestic athletes. According to French experts, mildronate tends to accumulate and persist in the body for up to 120 days.
Back in October 2015, it was decided at the international level by the Anti-Doping Commission to include the drug mildronate-meldonium in the monitoring list. The decision to ban came into force on 1 January 2016, while the doping scandal broke out in March.
Indications for the use of meldonium:
How to use and dosage:
Due to the possibility of developing an excitatory effect, it is recommended to use the drug in the morning and no later than 5 p.m. (if taken several times a day).
Athletes take 0.5-1.0 g orally 2 times a day before training. Course duration during the preparatory period - 2-3 weeks, during the competition and after them for 5 days in the same dosage.
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